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pentobarbital will lower the extent or influence of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Use of different treatment plans is strongly advisable when linagliptin would be to be administered that has a CYP3A4 inducerShould the buprenorphine dose is inadequate as well as CYP3A4 inducer can't be les